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the methods and uses become methods and uses for inhibiting angiogenesis, comprising contacting a tissue comprising, or a population of, angiogenic or potentially angiogenic blood vessels, i.e., those exposed to or potentially exposed to VEGF, with an anti-angiogenic composition comprising a biologically effective amount of at least a first VEGFR2-blocking, anti-VEGF antibody of the invention, or an antigen-binding fragment thereof, under conditions effective to inhibit angiogenesis