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A liposome is not a fixed, stable object: it is a microscopic fat droplet that naturally tends to merge with other liposomes, fall apart, or leak its contents, particularly during storage

FIGURE 4 4 Comparative overview of mainstream GLP-1RAs Over the past 2 decades, several GLP-1RAs have entered clinical practice, including short-acting exenatide, intermediate-acting liraglutide, and long-acting formulations such as dulaglutide and semaglutide, as well as the newer dual agonist tirzepatide

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As explained, there is a rationale for the combined use of basal insulin and GLP-1RAs