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4.3 Metabolite signaling Short-chain fatty acids (SCFAs)primarily acetate, propionate, and butyrateare the most extensively characterized microbiota-derived metabolites in BGMA communication

doi: 10.1016/j.jdiacomp.2018.11.012 36 SarkarGAlattarMBrownRJQuonMJHarlanDMRotherKI

A healthcare provider gives initial training on self-injection

Key highlights: More patients achieved 3050% pain reduction vs placebo Relief continued over 12 months Improvements in sleep quality and mobility No signs of dependence or withdrawal For millions living with chronic back pain, these results point to a promising new option backed by rigorous research