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Higher DZN doses increased oxidative stress markers and altered antioxidant enzyme activities, leading to significant tissue damage, particularly in the brain [40]

The major advantage of this approach is that small molecules have a considerable higher bioavailability compared to antibodies, dominant-negative receptors and antisense oligonucleotides

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Indole-3-propionic acid is a potent hydroxyl radical scavenger produced exclusively by the commensal gut bacteria Clostridium sporogenes 66 and normally found in the plasma and cerebrospinal fluid