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Summary: Even at tiny doses, Dihexa may be extremely active in the brain

G., Meadows, G

Cycle guidelines Cycle guidelines Approach Phase 2 reference Duration 48 weeks Review Point Every 4 weeks at each dose step Best For Matches the original NEJM trial structure Approach Phase 3 TRIUMPH reference Duration 68-72 weeks Review Point Every 4 weeks

Early discontinuation may be overestimated if treatment occurred outside the purview of the claims data source 13 KESIMPTA received approval in August 2020, resulting in a relatively limited number of patients with sufficient real-world follow-up data to assess persistence and adherence