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Moreover, astrocytes in AD often exhibit impaired phagocytic capacity and defective immune clearance, resulting in the accumulation of neuronal debris and secondary iron release, further exacerbating local cytotoxicity and iron dyshomeostasis (Zeng et al., 2025)

Abstract: Wijendran, V., & Hayes, K

The rd1 mouse is a common animal model used to study RP in which the expression of over 60 genes, related to proliferation, apoptosis, and transcription, is modified via a mutation in the phosphodiesterase-6 gene, which affects the metabolism of cyclic guanosine monophosphate

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