Future direction The evolution of GLP-1RAs is increasingly shifting toward oral formulations, aiming to enhance patient adherence by eliminating the need for injections and addressing the logistical complexities associated with traditional peptide therapies [72, 73]
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Moreover, the ICRS visual histological scores 51 , osteoarthritis cartilage histopathology assessment system (OARSI) 52 , hyaline cartilage defect distance, and relative expression of COL II were quantitively evaluated based on the results of H&E staining, toluidine blue staining, Safranin O/Fast Green staining, and COL II immunohistochemical staining, respectively
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