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While the cysteine decomposition is coupled with mitochondrial bioenergetics in the cells with intact KEAP1-NRF2 system, in NRF2-addicted cancer cells, most of the available cysteine appears to flow into the anabolic pathway, namely, glutathione synthesis and leaves the catabolic pathway in mitochondria, which is consistent with the observation that mitochondrial respiration is limited in NRF2-addicted cancer cells (Sayin et al

Cellular Repair: You wake up feeling restored and recovered rather than depleted and haggard

[DOI] [PubMed] [Google Scholar] 19.Liu YS, Xu GY, Cheng DQ, Li YM

Mice within the control group were subjected to intraperitoneal administration of the same volume of saline