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SURMOUNT-1 enrolled 2,539 adults with a mean baseline BMI of 38.0, and 94.5% of participants had a BMI of 30 or higher
The approval is based on 2 phase 3 studies, REMIX-1 ( Results of the trials showed that patients on remibrutinib achieved well-controlled disease as early as week 2
This novel functionality of ORF3a, different from targeting autophagosome-lysosome fusion, is a selective impediment of STING-mediated autophagy, thereby promoting viral proliferation
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