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Certain toothpaste ingredients, including cinnamic aldehyde and sodium lauryl sulfate, can trigger allergic contact dermatitis in the perioral zone in sensitive individuals

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However, resveratrol has been reported to inhibit cell growth and induce apoptosis in normal cells at high doses, with studies showing that mice consuming large doses experienced fatal outcomes within 34 months [75,76,77,78]

Future investigations should aim to unify metabolic, structural, and signaling insights to better exploit erythrocyte plasticity for use in precision medicine