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However, the available evidence strongly suggests that smoking acts as an independent risk factor that exacerbates the severity and progression of chronic viral hepatitis, increasing the risk of advanced fibrosis and cirrhosis, and potentially impacting treatment efficacy

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Cascone T, Sepesi B, Lin HY, Kalhor N, Parra ER, Jiang M, Godoy MCB, Zhang J, Fossella FV, Tsao AS, Lam VK, Lu C, Mott FE, Simon GR, Antonoff MB, Mehran RJ, Rice DC, Behrens C, Weissferdt A, Moran C, Vaporciyan AA, Lee JJ, Swisher SG , Gibbons DL, Wistuba II, William WN Jr, Heymach JV