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Previously, we have shown that C2C12 mouse myoblasts genetically modified to express human LMNA (hLMNA) gene bearing R482L mutation exhibited alterations in coordination of cell cycle dynamics and muscle differentiation, mitochondrial uncoupling, and a decrease in glycolytic activity in skeletal muscle myofiber 18,19,20

Safety in a FIH trial is managed pro-actively it's built into the design from day one

SB-01 clinical trials: The synthetic peptide SB-01, which targets TGF-beta-1 signaling in degenerated discs, is currently in clinical trials

Structural differences between classes of GST can therefore be utilised to develop new anti-cancer drugs