semaglutide after reaching goal weight My thoughts 12 months on Wegovy (and a loss of 88 lbs) : r/ Reached goal weight : r/Semaglutide

Overall, this corresponded to seven fewer new diagnoses of substance use disorder for every 1,000 people taking a GLP-1 medication

But the precision challenge intensifies

The existing evidence base consists primarily of: Small observational studies in patients with diabetes who also have inflammatory conditions Mechanistic studies exploring theoretical anti-inflammatory pathways Indirect evidence from cardiovascular outcome trials showing reduced inflammatory markers in people with type 2 diabetes (which cannot be extrapolated to rheumatoid arthritis or to microdosing) NICE guidance for rheumatoid arthritis management (NG100) does not include GLP-1 receptor agonists among recommended treatment options

Int J Pharmacol Ther 2014