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Specifically, we used genetic variants to predict l-carnitine, and obtained their associations with coronary artery disease (CAD), ischemic stroke, heart failure, and atrial fibrillation, as well as CVD risk factors (type 2 diabetes, glucose, HbA1c, insulin, lipid profile, blood pressure and body mass index) in large consortia and established cohorts, as well as sex-specific association in the UK Biobank

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For example, a 5 mol/L elevation in Hcy concentration has been correlated with a 0.5 mmHg rise in diastolic blood pressure and a 0.7 mmHg increase in systolic blood pressure