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For individuals participating in retatrutide clinical trials, practical management of skin sensitivity begins with good injection technique and site rotation, following the instructions provided by the trial team
QOL was also superior in the docetaxel arms compared with mitoxantrone ( P = .009).[60][Levels of evidence A1 and A3] In another randomized trial involving patients with hormone-refractory prostate cancer, a 3-week regimen of estramustine (280 mg PO tid for days 1 to 5, plus daily warfarin and 325 mg aspirin to prevent vascular thrombosis), and docetaxel (60 mg/m2 IV on day 2, preceded by dexamethasone [20 mg 3 starting the night before]) was compared with mitoxantrone (12 mg/m2 IV every 3 weeks) plus prednisone (5 mg qd).[61][Level of evidence A1] After a median follow-up of 32 months, median OS was 17.5 months in the estramustine/docetaxel arm versus 15.6 months in the mitoxantrone arm (HR death, 0.80
That's meaningful but not transformative