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However, UPR can also activate downstream apoptotic signaling pathways and promote apoptosis when the damage is persistent and severe or when the extent of the crosstalk network exceeds the resolution capacity of ER loading aberrations (55)

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Peptide vaccines have been studied in combination with chemotherapy agents and drugs not intended to treat cancer, with promising results

Unlike combining two incretin-based peptides (which should never be done due to stacked GI side effects and receptor overstimulation), this combination targets completely separate biological systems