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The larger the meal size and the faster the stomach empties, the greater the level of glucagon-like peptide-1 [11]
This is the pharmacological basis for CagriSema : in REDEFINE 1, the combination produced 20.4% mean weight loss versus 11.8% for cagrilintide alone and 14.9% for semaglutide alone
This is remarkable progress given the historical trends with previous anti-obesity medications used (i.e., Phentermine, Low Dose Naltrexone, Orlistat, etc.) were only noted to produce an average of 3-7% total percentage of body weight lost
It might do this by influencing the renin-angiotensin-aldosterone system, which is important for controlling blood pressure
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