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This notion is in stark contrast to the well-known anti-diabetic properties of BAs sequestrants, (343) and some, have proven to elicit GLP-1 secretion via TGR5 mediated PC1/3 upregulation (344)

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Clinical studies have shown that endothelial dysfunction, hyperlipidemia, oxidative stress, and platelet hyperactivity are important factors in the development of atherosclerotic vascular problems (2)