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how fMRI shows dehydration shrinks brain tissue and forces it to work harder for the same output (Kempton 2011)

Lancet 1961;277:e3 Chandran R, Khammissa RA, Lemmer J, Feller L

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The mechanistic origins of all these defects are not well understood, and no placebo-controlled randomized clinical trial (RCT) has successfully shown the reversal of multiple such age-associated defects in OA