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Known risks include injection-site reactions, water retention with GH peptides, potential interactions with existing medications, and theoretical concerns around telomerase activation in the context of cancer risk

For Aetna Medicaid managed care plans, coverage varies by state

For skin tightening, ultrasound or radiofrequency treatments are commonly used

In the CY 2025 PFS final rule (89 FR 97763), we acknowledged the utilization of this flexibility and stated we recognized that many practitioners have stressed the importance of maintaining it but were seeking additional information regarding potential patient safety and quality of care concerns