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doi: 10.3389/fcell.2020.603837 Received 08 September 2020 Accepted 30 November 2020 Published 12 January 2021 Volume 8 - 2020 Edited by Sergio Giannattasio, Consiglio Nazionale delle Ricerche, Istituto di Biomembrane, Bioenergetica e Biotecnologie Molecolari (IBIOM), Italy Reviewed by Cesare Indiveri, University of Calabria, Italy

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Cryo-electron microscopy studies (Li et al., 2024, Cell Discovery) revealed the peptide adopts a single continuous helix achieving balanced activation through conserved interactions and receptor-specific transmembrane domain contacts

Numerous agents of this class have shown promising results in different in vitro and in vivo models of chronic fatigue/CFS, predominantly by counteracting oxidative stress and the inflammatory cascade