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The gut-brain axis is implicated in this since it is the bidirectional communication network between the gastrointestinal tract and the central nervous system (Hsieh et al., 2011

4f, quantification: Fig

While Novo Nordisk currently benefits from its established market leadership, Eli Lilly is expected to intensify competition through its oral GLP-1 pipeline, with long-term success likely to depend on demonstrating superior real-world outcomes while differentiating its therapies through efficacy, safety, pricing, and patient convenience