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When combined, the risk of serotonin syndrome, a potentially life-threatening condition, increases, as both medications can influence serotonin levels in the brain. Serotonin might be the bodys feel good chemical, but serotonin syndrome may cause nausea, vomiting, diarrhea, and tremors when its mild or high blood pressure, racing heart rate, seizures, and fainting when its more severe

All eligible subjects signed university-approved informed consent documents and approval was granted by the Institutional Review Board for the Protection of Human Subjects of Baylor University and Research Ethical Review Committee of Kyowa Hakko Kirin Co., Ltd

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