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Instead, therapeutic modulation of GSH must be tailored to disease context, reflecting the fundamental GSH paradox: whereas cancer therapy often seeks to deplete elevated GSH to induce oxidative stress and cell death, neurodegenerative and inflammatory diseases may require restoration of GSH homeostasis
Four histological grades of melanosis have been defined as Grade 1 variants, with only a few cells containing pigment granules, up to grade 4, in which the pigmented cells are extended and are located below the muscularis mucosae, lymphatic vessels and regional lymph nodes