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The gut-thyroid-GLP-1 triangle One of the most fascinating aspects of GLP-1 therapy in Hashimoto's patients is the three-way relationship between gut health, thyroid function, and GLP-1 signaling

(Endocrinology, 2010), demonstrated a strong species-dependent effect: In rodents: High GLP-1 receptor expression in thyroid C-cells Strong cAMP signaling activation Persistent stimulation leads to tumor formation In humans and primates: Minimal or absent functional GLP-1 receptor expression in C-cells No meaningful calcitonin elevation under therapeutic exposure No observed C-cell proliferation in long-term studies Even exposure levels far exceeding clinical doses failed to reproduce rodent-like thyroid effects in primate models

The primary endpoint was percent change in body weight

Getting labs through your primary care physician before starting is a good practice