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qRT-PCR analysis (Figure 2E) showed that FOXO4-DRI-treated PDL9 cells displayed enhanced SOX9 expression, and reduced MMP12 and MMP13 expression, which however were at the expense of lower expression levels of COL2
Neither side effect profile is objectively worse, they are just different, and your individual tolerance matters
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In addition, glutamine uptake can be negatively regulated by retinoblastoma (Rb) tumor suppressor family, whose deletion increases glutamine uptake via the E2F -dependent upregulation of SLC1A5/ASCT2 and GLS1 [22]
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