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Here, we demonstrated that a combination of 3 major antioxidants in the human body (glutathione, ascorbic acid and uric acid) allowed for human gut Clostridia to thrive and maintain microbial production of the key molecule butyrate in the presence of oxygen (in aerobiosis)

Additionally, NAD + is required for fatty acid metabolism during -oxidation, glutaminolysis generating -ketoglutarate, mitochondrial shuttling of metabolites, and lactic acid fermentation 3,4,5

The extensive tissue accumulation relative to plasma requires consideration when interpreting experimental results

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