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Studies were included if they provided relevant results on efficacy outcomes related to weight management or diabetes, or if they provided relevant safety outcomes related to psychiatric events such as worsening of psychiatric conditions or suicidality

Curcumin exerts an anti-inflammatory effect through inhibition of NF- [137], a COX-2 activator, explaining its possible therapeutic effect against PE, where higher placental levels of thromboxane related to COX-2 expression (a potent vasoconstrictor) are evident [138]

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