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We also wish to thank Peter Ravn (MedImmune Ltd, Cambridge, UK) for intellectual input into GLP-1 analogue peptide stabilization, Bojana Popovic and Daniel Cannon (MedImmune Ltd, Cambridge, UK) for generating and analysing the peptide homology model, Adrian Podmore (MedImmune Ltd, Cambridge, UK) for conducting the aggregation and stability testing, Richard Kay (LGC, Fordham, UK) for conducting the mass spectrometry metabolites identification work, Marcella Petrone and John Hood (MedImmune Ltd, Cambridge, UK) for performing PK-PD simulations and analysis as well as Christopher Rhodes (MedImmune LLC, Gaithersburg, MD, USA) for his critical review of this manuscript
Finally, a 26-week, double-blind trial evaluated the efficacy and safety of ertugliflozin in T2DM patients who were inadequately controlled (HbA1c, 7.010.5%) after a minimum of 8 weeks of metformin therapy ( 1500 mg/day) [55]
If things get worse, stop and reassess the ingredient list (peppermint intensity, sugar alcohols, high-FODMAP fibers, or simply too high a dose)
