: The first reaction is rate-limiting and is catalysed by glutamate cysteine ligase (GCL, EC 6.3.2.2
While glutathione is naturally present in the body and available through certain foods, factors like stress, illness, and age can deplete its levels
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These processes may result in NF-B activation and maybe promote the expression of IL-1, IL-6 and TNF- in microglia (Fig
