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16 As noted in Table 1, data documenting a strong association between adjuvant treatment and outcomes after surgical treatment of MMNSTs are lacking

In the STEP trials, semaglutide was administered as part of a comprehensive lifestyle intervention that included a reduced-calorie diet (approximately 500 kcal/day deficit based on baseline energy requirements) and a minimum of 150 min of physical activity per week [38,39,40,41,42,43,44,45,46, 78, 97]

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Notwithstanding the reported differences, this cellular distribution characteristic may lend itself to alternative strategies to interfere with AR action, also in CRPC cells