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Differences in brain metabolite levels using MRS have been reported for autistic individuals in multiple brain regions including: the primary sensorimotor cortex SM1(He et al., 2021

Interestingly, agmatine, a metabolite produced by the gut bacterium Bacteroides vulgatus was shown to impair ovarian function by inhibiting GLP-1 secretion through activation of the farnesoid X receptor (FXR) (Yun et al., 2024)

Taking occasional "breaks" or cycling your supplements can also be a helpful strategy for some people

Mental Health and Depression DSIP appears to influence serotonin metabolism and monoamine oxidase activity, which are critical in mood regulation ( 8, 10 )