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Reported Adverse Effects Reported adverse effects from online forums cited in a 2025 systematic review (PMC12313605) included: Anxiety and panic attacks Depression and anhedonia Insomnia Heart palpitations Fatigue and weakness Loss of appetite These anecdotal reports cannot be verified as directly caused by BPC-157 versus contamination, incorrect dosing, or concurrent conditions, but they raise concerns that the peptide might paradoxically worsen mental health in some individuals

Treatments for keloids remain unsatisfactory because the key pathophysiological mechanism is unknown 1

BPC 157 has been investigated for its potential role in modulating nitric oxide signaling and vascular growth factor pathways