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Cerebellar ataxia, with or without vermian atrophy, was described only recently in relation to AIFM1 mutations, and has further widened the symptomatology [160]

78, 79 One of the ways EGFR activation protects from experimental colitis in mice is by restituting Na + homeostasis

This systemic inflammation, akin to the processes described in schizophrenia, can traverse the blood-brain barrier or transmit via vagal afferents, subsequently activating microglia and exacerbating neuroinflammatory processes while impairing prefrontal cortex-mediated executive functions including decision-making and emotional regulation (270)