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How the Three Pathways Work Together What makes the design work is that the three receptor pathways complement each other: GLP-1 reduces energy intake (you eat less) GIP optimizes how that energy is used (better insulin sensitivity, favorable fat distribution) Glucagon increases energy expenditure (you burn more calories at rest and mobilize stored fat) The net effect: you eat less, your body uses energy more efficiently, and you burn more calories at rest
The unusually high consumption of vitamin B12 can lead to an insufficient supply of it and a vicious cycle starts
Theoretically, the accumulation of unfolded proteins in the ER can cause ER stress and lead to unfolded protein response 44
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