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However, the transition from traditional use to clinical practice requires overcoming significant regulatory challenges, particularly regarding the standardization of phytochemical profiles and batch-to-batch consistency

In addition to elevated CRP, IL-6, and TNF-, shift workers show altered immune profiles such as a reduced CD4 + /CD8 + T-cell ratio, increased monocyte counts, and impaired NK cell cytotoxicity

One significant contribution was made by Hyman Zimmerman in the 1960s, who observed that patients exhibiting hepatocellular DILI alongside jaundice had a notably elevated risk (between 10 and 50%) of progressing to acute liver failureduring a time when liver transplantation was not yet an option

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