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The change in molar ellipticity observed in the range from ~210 to ~250 nm, with a maximal change at 222 nm, clearly indicates that the MT2 conformation, which is hardly observable in CD spectra, changes during the reaction due to Zn(II) dissociation and Cys residue alkylation

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This pulsatility is important for normal physiological effectscontinuous GH exposure can cause receptor downregulation

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