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In addition to GLP-1RAs, pioglitazone and SGLT-2 inhibitors are two other classes of diabetic medications that have shown promise in reducing the risk of cardiovascular disease, albeit through different mechanisms

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The American Journal of Chinese Medicine , 49 (07), 1645-1666

For instance, MCT1 inhibition in glycolytic tumors induces a metabolic catastrophe that triggers caspase-dependent apoptosis alongside GSH depletion-mediated ferroptosis, thereby yielding enhanced antitumor efficacy relative to the activation of either pathway alone (142)