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This triple-receptor profile distinguishes Retatrutide from many earlier peptide research compounds that focus on a single receptor pathway or dual receptor model

If upregulation of citrate synthase occurred due to excess PPA in vivo and then PPA was removed in vitro , the high activity of citrate synthase in vitro would overproduce citrate and enhance the proximal portion of the TCAC, which preferentially produces NADH, the electron carrier metabolized by complex I