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Introduction Incretin-based therapies have been suggested to increase the risk of pancreatitis [13], but evaluation of the true risk is hampered by the small number of cases included in individual phase II and III clinical trials

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Analysis of subgroup of patients with HF in the EXSCEL trial revelaed that use of once-weekly exenatide reduced the risk of all-cause mortality in patient without HF (HR 0.79 [95% CI, 0.680.92]), while in patients with baseline HF no effect was observed (HR, 1.05 [95% CI, 0.851.29) (67)

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