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34 A prospective, singlearm, multicentre study in Japan, evaluating 58 patients who switched from exenatide twice daily to exenatide ER, observed improved glycaemic control (HbA 1c decrease of 0.2%point over 24 weeks)

It based its decision on the results from the The company states that the trial found that Victoza led to: a 22% reduction in cardiovascular death compared with a placebo a 12% lower risk of non-fatal heart attack an 11% risk reduction of non-fatal strokes Trulicity (dulaglutide) In 2020 the FDA approved Trulicity (dulaglutide) for the reduction of major adverse cardiovascular events (MACE) in adults with type 2 diabetes who have established cardiovascular disease or multiple cardiovascular risk factors

In contrast, Wegovy-related symptoms tend to be more insidious in onset and are often gastrointestinal-predominant

Some studies indicate that high sodium intake may affect insulin signalling pathways and contribute to oxidative stress, potentially exacerbating metabolic dysfunction