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For semaglutide, there are several key contraindications: Personal or Family History of Medullary Thyroid Carcinoma (MTC): Semaglutide is not recommended for people who have or have had MTC or if their family has a history of this type of thyroid cancer

These effects may impair individual functioning and contribute to broader public-health concerns, including increased engagement in risky behaviours and an elevated mental-health burden

Specifically, the gut microbiota has been shown to play an important role in gut hormone modulation, including GLP-1