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The following photomicrographs were taken from representative areas of this mass

The injectable obesity medications Semaglutide 2.4 mg, a selective GLP-1 receptor agonist, produces robust and durable weight loss of approximately 1516% over 68 weeks ( Tirzepatide, a dual gastric inhibitory polypeptide (GIP)/GLP-1 receptor agonist, delivers even greater weight loss, exceeding 20% at the highest dose in pivotal trials ( Retatrutide, a triple agonist targeting GIP, GLP-1, and glucagon receptors, represents a further step in efficacy, with 24.2% weight loss achieved within 48 weeks in phase 2 studies ( Survodutide, an oxyntomodulin analogue, achieved clinically meaningful weight loss ( Table 2

The weight loss application of semaglutide accelerated after Novo Nordisk launched Wegovy in June 2021, the first GLP-1 explicitly approved by the FDA for chronic weight management in adults

Methods Use of experimental animals FVB/Mdr2 / knockout (gift of Dr