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The confusion comes from misreading the SURPASS-2 trial (Fras et al., New England Journal of Medicine 2021), which compared tirzepatide to semaglutide 1 mg in type 2 diabetes patients

However, multicenter studies have shown no significant difference in local recurrence rates between EA (44%) and Enneking-inappropriate (EI) resections (33%) ( In this case, local recurrence occurred within three months postoperatively, suggesting that conventional en bloc resection may be insufficient to eliminate microscopic perineural spread