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In contrast to benign melanocytic lesions, RASSF10 was found to be frequently hypermethylated in melanoma [45]

doi: 10.1097/MPH.0b013e31815815ae Summary Keywords MNTI, clinicopathological features, BRAF , mutation, recurrence Citation Xia R-H, Zhang C-Y, Wang L-Z, Hu Y-H, Sun J-J, Tian Z and Li J (2021) Melanotic Neuroectodermal Tumor of Infancy: A Clinicopathological and BRAF V600E Mutation Study of 11 Cases

The protective effect was seen across a wide variety of addictive and habit-forming substances, including cocaine, opioids, alcohol, nicotine and cannabis, adding further evidence to a phenomenon previously flagged in smaller studies