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Beyond two years A large study published in 2024 followed 17,604 adults and found that people taking semaglutide kept losing weight for about 65 weeks and were able to maintain their weight loss for up to 4 years

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While many patients tolerate GLP-1 medications well, some may experience mild side effects as their body adjusts: Nausea Digestive changes, like feeling full more quickly Occasional fatigue These effects usually lessen over time