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Because Rybelsus slows down how quickly food leaves the stomach, the most common adverse reactions reported with Rybelsus were gastrointestinal and included (Novo Nordisk, 2021): Nausea Stomach pain Diarrhea Decreased appetite Vomiting Constipation Other less common but potentially serious side effects include: Risk of thyroid tumors Pancreatitis Complications in people with diabetic eye disease Low blood sugar (when used with insulin or other medications that lower blood sugar) Kidney disease Allergic reactions Dosage Rybelsus comes as oral tablets available in 3 mg, 7 mg, and 14 mg doses

For topical use, standard concentration is 24% applied once or twice daily

Participants received semaglutide or a placebo for 26 weeks