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What they found: Prevention of age-related changes in gene expression , NMN-treated mice had an expression profile closer to young mice Restoration of mitochondrial function in multiple tissues Improvement of insulin sensitivity of 35 to 50 % Preserved muscle strength and endurance Preserved bone density Better vision (NMN-treated mice had a slower decline in ophthalmologic parameters) No serious adverse effects Why it matters: This is the most ambitious preclinical study of NMN/NAD+ in animal aging models

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Available from: Accessed 8 Dec 2024

Their research demonstrated that melatonin treatment could enhance estradiol levels by modulating the activity of steroidogenic enzymes (3-HSD and 17-HSD), thereby fostering reproductive health in individuals affected by PCOS