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These recommendations included: Suspension of the PPS project and associated funding

Glutathione helps break down these toxic byproducts

Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny

While many of these molecules showed promising results in preclinical rodent, minipig, or non-human primate (NHP) models, they could not achieve sufficient therapeutic windows to observe clinical weight loss without adverse events such as cardiac activation (6)