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GPx4 uses the reducing power of glutathione to convert highly toxic lipid hydroperoxides into harmless, non-toxic lipid alcohols

Pharmacological strategies that block PERK, NF-B, or NLRP3 have reduced TMAO induced inflammation in preclinical models, indicating their translatable potential

doi: 10.1038/jp.2009.24 184 QuintosJBBoneyCM

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